Wet granulation method of tablet.
Figure 1: Wet Granulation process for effervescent tablets.
Wet granulation method of tablet Apr 28, 2018 · It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. Jan 1, 2011 · Granulation of a powder or mixture of powder is done in order to improve flow, uniformity of contents, better compressibility, improve density and to aid pharmaceutical dosing of the 2 days ago · Wet granulation is a critical process in tablet manufacturing that enhances the flowability, compressibility, and homogeneity of powder blends. Wet granulation. Purushothaman 2 , C. This method involves various steps like weighing of ingredients, mixing, granulation, and screening of Among the most common techniques for tablet manufacturing are direct compression, dry granulation, and wet granulation. Batches of paracetamol tablets were formulated using 2, 5, 10 wand 20% / w of date palm powder. Paracetamol, lactose, date General methods of tablet preparation: • Wet Granulation • The most widely used and most general method. Granules containing 500mg of paracetamol per tablet are prepared and submitted. J. 3 days ago · The tablets was granulated using wet granulation method as follows. Wet granulation involves using a liquid such as water to form granules, then drying the granules. [4] The term direct in the manufacture of tablets by wet granulation, Jan 1, 2023 · Conclusion: The prepared tablets by wet granulation method using PVP solution had more tablet hardness. . Mixing (blending) by addition of glidant and lubricant. Granulation by sieving (wet screening). Wet granulation involves using a liquid to form granules and allows for a wide range of excipients. The steps involved in the wet method are weighing, mixing, and granulation, screening the damp mass, drying, dry screening, lubrication and compression [33]. methods of tablet manufacturing wet granulation and direct compression are widely used in the pharmaceutical industries. Wet Granulation Aug 10, 2015 · Granulation is a standout amongst the most vital unit tasks in the generation of pharmaceutical oral measurements frames. Based on API type and excipient’s nature suitable tablet manufacturing method is been selected. Especially, high shear granulation is still the most commonly used in pharmaceutical industry as it offers several advantages over the other methods such as short processing time, uniform size distribution of granules with reproducibility, and dense granules Oct 10, 2019 · Compressed tablets can be made using a wet-granulation process followed by compression or simply by direct compression (DC). Dissolution Rate Aug 14, 2023 · Wet granulation is a common process used in the pharmaceutical industry to produce tablets, capsules, and other solid dosage forms. As the primary component of API-A tablets is a fine powder with an average diameter of about 10 µm, which is highly adhesive and has poor flowability, we used a wet granulation method for tablet production, in contrast to the direct compression method in our previous reports [15], [16]. Granule strength results evaluated by uniaxial confined compression analysis were compared to the tensile strength of resulting tablets. What are the advantages and disadvantages of Wet Granulation. 2 Manufacture of tablets by dry granulation method. A common formulation was chosen to be processed with both wet and dry granulation techniques: roll compaction/dry granulation, high-shear granulation, twin-screw granulation, and fluidized-bed granulation. 1. Importance. It defines granulation as a process where small particles adhere together through bonding, forming larger aggregates called granules. In this technique, the acid and bicarbonate components can be granulated either separately or as a mixture with ethanol, ethanol-water mixture, isopropanol, etc. Key steps in the wet granulation process are outlined, including weighing and sifting powders, blending, wet granulation, drying, dry screening, and lubrication. The data indicated that wet-granulation tablets give slower drug release than direct-compres-sion tablets, and that a higher level of 71G NF is required in direct com-pression in order to achieve drug release equivalent to that of the wet granulation method. Dec 22, 2021 · The research is a formulation of diclofenac sodium as a effervescent tablet by wet granulation method. DC tableting has been steadily increasing in acceptance and use since the 1960s, when the first excipients suitable for DC tableting were developed 2. In wet Granulation, suitable granulating fluid like water, binder solution, or organic solvent is added along Jan 21, 2025 · Wet granulation is one of the most common technological processes in pharmaceutical production and has found its application in many industries. Dec 23, 2016 · The document describes three main methods for manufacturing tablets: wet granulation, dry granulation, and direct compression. 2 Roller Compaction; 9. The granule mixtures compressed into tablets by a single-punch press machine (KILIAN & CO, Germany), with 25 mm punch set. In dry Feb 5, 2024 · Tablets Manufacturing Methods and Granulation Techniques – By I. Wet Granulation The most widely used process of agglomeration [1-7] in pharmaceutical industry is wet granulation. Wet granulation is carried out in two ways – one method is to moisten the powder or powder mixture and pass it through a screen of the mesh size needed to produce granules in Mar 12, 2024 · Differences between wet granulation and dry granulation methods. Oct 19, 2023 · Discover the pivotal role of granulation in pharmaceutical manufacturing, transforming fine powders into granules for improved tablet production. Mar 29, 2016 · It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. Each formulation was composed of drug and excipients in various proportions. Methods of Granulation • Dry granulation • Wet granulation (involving wet massing) • In a suitable formulation a number of different excipients will be needed in addition to the drug. The technique is not easy, especially in the absence of the right equipment. The direct compression method has lower cost due to reduced labor, power consumption, equipments, time, and space but wet granulation has high cost. Nov 10, 2017 · It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. For formulation What is Wet Granulation? Wet granulation is a process where small powder particles are stuck together using a liquid binder to form bigger, easier-to-handle particles called granules. Each method has its advantages and challenges, making the choice dependent on factors like the formulation, desired tablet properties, and manufacturing capabilities. lubricant combination are agents added in small quantities to the tablet during tablet preparation . It is a reproducible process and suitable to produce granules that are compressed into May 1, 2019 · Among the granulation techniques, wet granulation method can be the most popular one. May 3, 2024 · Conducting tests in a wet state allows the application of this approach at an early stage in the manufacturing process. 10 According to this invention, the binder solution was prepared initially and the dry powder excipients Nov 19, 2021 · WET GRANULATION. Aspirin belonging to the class of NSAID Mar 11, 2022 · This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. May 1, 2022 · Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms. Homogenizing by second sieving (dry screening). 2. 4. There are two key types of granulation processes: wet granulation, where a liquid is used to agglomerate the powder, and dry granulation or roller compaction, where the powders are compressed together to form granules. PVP as a binding agent. Atorvastatin calcium (amorphous) is highly susceptible to hydrolysis and oxidation. Wet Granulation [9-21] is observed which the disadvantage of this method is. It involves the production of granules by adding granulation liquid to the mixture of the active ingredient and excipients. 3 days ago · Wet granulation is a fundamental process in tablet manufacturing, enabling the production of high-quality tablets with improved properties and content uniformity. Preformulation and drug excipient compatibility study, prototype formulation carried out for the highest dose of Atorvastatin calcium (80 mg) and optimized to get the final formula. Slug screening The dry granulation method (slugging method) The ingredients in the formulation are intimately mixed and precompressed on heavy duty tablet machines. 2. Advancement Wet Granulation Techniques. Wet granulation process simply involves wet massing [8-15] of the powder blend with a granulating liquid, wet sizing and drying. The most widely used process of agglomeration [1-7] in pharmaceutical industry is wet granulation. Wet Granulation. The bitter taste of the drug are masked by added sweetening agent (lactose, glucose etc. , 2020) with permission from Elsevier. Wet Granulation; Dry Granulation We will discuss each method of granulation in detail based on practical experience & observations but first have a look at the basic concept of granulation. Wet Granulation; Dry Granulation There is a difference between these two methods of granulation i. wet granulation and dry granulation. Wet granulation was performed on F 5 and F 6 formulations. Read more about. Conclusion Dec 4, 2021 · Manufacturing process depends on many factors, including the compression properties of the therapeutic agents, the particle size of the therapeutic agent, excipients and the chemical stability of the therapeutic agent throughout the producing method. The slug which is formed is ground to a uniform size and compressed into the finished tablet. May 27, 2024 · Metronidazole tablets were formulated with four different binder vis, acacia, gelatine, PVP, maize starch at 3% concentration using wet granulation method after which the tablet properties were Apr 3, 2018 · The document discusses various tablet granulation techniques. 4 days ago · The usual methods of formulation include wet granulation, dry granulation and direct compression. Dec 1, 2018 · Four granulation techniques were compared evaluating their impact on granule properties and the tablet tensile strength. Dec 10, 2024 · The wet granulation process is the most widely used OSD method and involves multiple steps that transform a range of powders and ingredients into granules, which in turn are made into tablets. et al Wet granulation. Especially, high shear granulation is still the most commonly used in pharmaceutical industry as it offers several advantages over the other methods such as short processing time, uniform size distribution of granules with reproducibility, and dense granules wet-granulation tablets containing 71G NF or 971P NF. Wet granulation is the most commonly used method for the production of compressed tablets. In the traditional wet granulation method the wet mass is forced through a sieve to produce wet granules which are subsequently dried. The process of wet granulation can be very simple or complex depending on the characteristics of the initial powders, the final objective of tablet making, and the equipment that is available. Granulation of the powder material using a binder. After drying, dry screening was Apr 1, 2017 · Two most commonly used granulation techniques are wet granulation and dry granulation. • Its chief disadvantages are the number of separate steps involved, as well as the Dec 1, 2021 · Experimental set up for twin-screw wet granulation. Feb 8, 2024 · Bacterial cellulose (BC) is an interesting material for drug delivery applications due to its high purity. In addition to conventional granulation methods such as wet granulation and dry granulation, the review also outlines some new and improved methods from these two methods. Whether producing Immediate-Release Tablets, Film-Coated Tablets, or Mar 7, 2011 · To provide these tablet characteristics in accordance with the chosen ingredients, manufacturers can use three different processing technologies: direct compression, dry granulation and wet granulation. Both types of granulation can be operated as batch or continuous processes, depending on the industry and scale of the product Jan 28, 2013 · It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. Meshram ABSTRACT: Aspirin tablet is prepared by wet granulation method. Wet granulation technology makes use of multiple and more expensive equipment technology; thus has higher investment costs compared with dry granulation processes. ) In Feb 25, 2019 · It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. In -vitro release studies show that the formulation F3& F4 of wet granulation method and direct compression Sep 1, 2016 · In order to allow scaling of batch wet granulation processes, the potential to use the specific energy of granulation instead of granulation process parameters (R 2 = 1) was explored. Tablet Type: For example, Film-Coated Tablets may benefit from wet granulation for uniformity, while Compression-Coated Tablets require dry granulation for structural stability. Oct 9, 2016 · The dry granulation process involves the following steps: [14] Milling of drugs and excipients Combining ground-up powders Create slug by compressing into large, hard tablets. May 26, 2023 · Wet granulation process in tablet manufacturing is the most commonly used technique in the pharmaceutical industry as it produces granules with good compressibility and flow properties. There are two broad methods employed for granulating pharmaceutical formulations: dry granulation and wet granulation. Drying. Aug 25, 2020 · The document describes preparing and evaluating paracetamol granules using the wet granulation method. It produces tablets with good mechanical properties but requires multiple steps. Different methods are used for wet granulation, including fluidised bed, twin-screw extrusion, and high-shear method, leading to different mechanisms and granule properties. Saravanan 2 , C. By adding a liquid binder to dry powders, granules are formed, which improve tablet uniformity and quality. PREPARATION METHOD OF TABLET:- Tablets are prepared by three methods :- 1) Wet granulation method 2) Dry granulation method 3) Direct compression 1) Wet Granulation Method : – It is the most common and widely used method. Toll Free No. Mixing (blending) of the drug, diluent and disintegrant. The weight of each tablet was determined and the mean or average weight and standard deviation was computed. In Oct 18, 2020 · The following are commonly used methods of granulation for tablet manufacturing. The co-processed excipients were prepared by wet granulation technique by using MCC (PH102) and HPMC (K4M) in the ratio of 1:0. The selection of wet granulation or dry granulation depends upon nature of Active Pharmaceutical Ingredients. 1 Slugging; 9. Despite the many advantages of wet granulation, it also has limitations. Nov 10, 2020 · 1. In particular, techniques such as granulation in high- and low-shear mixers, fluidized bed granulation All the matrix tablets, each containing700 mg of paracetamol were prepared by wet granulation method. So wet granulation method was Feb 4, 2018 · Wet Granulation: Wet granulation requires powder particles, a granulating fluid, and a sieve. The choice of granulation method depends on several factors, including: API Properties: Moisture sensitivity, flowability, and compressibility of the active ingredients. In this study, we tried to apply this method considering the three factors, “Compressibility”, “Compactability”, and “Manufacturability”, with the single-punch tablet press (GTP-1) to set up the final formulation for a commercial tablet. Choosing between wet or dry granulation is probably the most important consideration when looking at granulation processes. Typically, wet granulation processes require more equipment and plant space than dry granulation technology. First, citric acid and sodium bicarbonate and potassium citrate were milled Jan 9, 2018 · formulated using wet granulation method and direct compression method and the tablets were evaluated for Weight variation, Hardness, Friability, in-vitro drug release, and disintegration. Direct compression is a popular choice because it provides the shortest, most effective and least complex way to produce Four granulation techniques were compared evaluating their impact on granule properties and the tablet tensile strength. It is most commonly used method for the manufacturing of tablets. Tablet Granulation Basic Concept Mar 1, 2022 · At present, according to the methods to promote the adhesion of powder particles, the granulation technology can be divided into two types, dry granulation and wet granulation [8]. Direct Compression for Tablet Manufacturing; Granulation for Tablet Manufacturing; Formulation Workflow; Dry Granulation; Wet Granulation; Continuous Manufacturing; Advantages of Mannitol in Tableting Processes May 12, 2023 · In this case, granulation produces larger and rougher particles. 6. • The common types used are diluents, to produce a unit dose weight of suitable size, and disintegrating agents, Among the granulation techniques, wet granulation method can be the most popular one. Mechanical compression of powder material to form granules. J. The most widely used and most general method of tablet preparation is the wet granulation method. Choosing wet or dry granulation . , 2018) with permission from Elsevier. While it does have some disadvantages, wet granulation remains a popular choice for formulating pharmaceutical tablets, especially for drugs with poor flow properties or those Dec 25, 2017 · Granulation is the main manufacturing process for the manufacturing of tablets. The tablet Dec 1, 2018 · It could be revealed that huge differences in granule strength and tabletability were related to the granulation method, whereby different conditions within a granulation method were of minor influence. 5. Jan 28, 2025 · Wet granulation is the size enlargement process where the fine powder particles are brought closer or are agglomerated with the help of binders & granulating fluid like water or IPA to form large, strong & permanent structures known as granules. Each method has its own set of advantages, disadvantages, and specific processes. 1 Manufacture of tablets by wet granulation method. Jan 28, 2025 · Granulation Methods Of Tablets Two types of tablet granulation methods are commonly used in pharmaceutical industries. For instance, granulated sugar is easier to compress into tablets compared to powdered sugar due to its better flow and compression characteristics. Granulation method can be broadly classified into two types: Wet granulation and Dry granulation. Selecting the appropriate process depends on a thorough understanding of the drug’s physicochemical properties, excipients, and desired flow and release characteristics. 18002679955 Email Us. Dry granulation is used to form granules without using a liquid solution because the materials to be granulated may be sensitive to moisture and heat. Manufacture of effervescent tablets using wet granulation method. Preparation of matrix tablets by using wet granulation technique The tablets of Atorvastatin were prepared by wet granulation method using PVP paste in the mixture of drug, polymers and PVP. It was granulated using 5% starch mucilage as binding agent and passed through no. The wet granulation method is the most widely used method. This is basically the same as for conventional tablets. The key granulation methods covered are wet granulation, dry granulation, and direct compression. The key granulation methods described are direct compression, dry granulation, wet granulation, and granulation by crystallization. Wet massing by addition of binder or adhesive or called granulation agent. Direct compression. In this Lubricants in combination leads to better drug release kinetic. Granulation specific energy has the advantage that it can easily be monitored online, and used to stop the granulator once a pre-determined high limit has been Download scientific diagram | Process flow chart for tablets manufactured by wet granulation from publication: Development of pH-independent matrix type sustained release drug delivery system of Jan 11, 2024 · Schupp shares his top five considerations when selecting the ideal granulation system for tablet manufacturing. 40 manually and mixed well to ensure the uniformity Mar 30, 2024 · The accumulation and production of tablets is essential to avoid segregation, creating a homogeneous mixture in many such materials. 8. The following case study shows how a fully functional Design Space, based on dynamic flow properties, can be outlined for a wet granulation process, facilitating the targeting of Critical Quality Attributes (CQAs) in the final tablet. Learn about dry, wet, and direct compression granulation methods and the key benefits of granulation in ensuring tablet quality and safety. e. The mechanism of wet granulation begins when liquid is added to the powder, causing wetting of the powder and the formation of a thin and immobile film Reverse wet granulation or reverse-phase wet granulation is a new development in the wet granulation technique that involves the immersion of the dry powder formulation into the binder liquid followed by controlled breakage to form granules. The obtained the granules were dried at 55ᵒc for 1 hr. Dry Granulation: Dry granulation is required when producing tablets from highly moisture and heat sensitive compounds. Wet granulation is a widely used tablet manufacturing process in the pharmaceutical industry. Granulation is the formation of small agglomerates called “granules”. It is of two types wet and dry that is adopted on the basis of the API used in the manufacturing. Wet granulation reduces the level of dust present during manufacturing process thereby reducing the incidence of cross-contamination and risk to workers. Dry granulation. Reprinted from (Ismail et al. Manufacturing tablets using the wet granulation technique increases the chances of meeting all physical requirements for tablet formation. 5 days ago · Pharmaceutical tablet manufacturing relies on two primary methods: direct compression and granulation. Wet granulation Method. 1 Flowchart of wet granulation process; 9. 9. Mar 1, 2022 · The primary methods of aggregate formation include solid bridging, bonding, sintering, chemical reaction, crystallization, and colloidal particle deposition [12]. Suresh 1 , M. Each granule will contain a proper mix of the ingredients of the formula. Download: Download high-res image (226KB) Download: Download full-size image; Fig. Shibu 1 *, S. C. Feb 13, 2023 · Wet granulation is the oldest method in the pharmaceutical industry. 3. BC used as diluents were prepared using two different methods: freeze-drying (BC-FD) and Steps of Wet Granulation 1. The wet granulation method Mar 3, 2020 · release tablet. Here are some of them: 1. Aspirin belonging to the class of NSAID having analgesic, antipyretic, anti-inflammatory and antiplatelet activity at systematic standard doses. Water or an organic solvent is either sprayed or poured into a blend to have its fine particles agglomerated into granules of a desired size with required flow properties. 5 It is crucial to have sufficient fines to fill the void spaces between granules, promoting better compaction, along May 16, 2021 · Tablets manufactured by wet granulation are amenable to post-processing unit operations such as tablet coating. Decision basis. A method commonly used for compressed tablet production, wet granulation involves a size enlargement process and an adhesive substance known as binder. The following are the advantages and disadvantages Apr 22, 2017 · Similar to wet granulation, the man ufacture of tablets by dr y gr an ulation involves the production and su bsequent compression of granules into the final dosage f orm. Material Loss There is minimal loss of material and cross contamination in the case of direct compression while cross contamination is high in wet granulation. The active ingredient, diluent and disintegrents are mixed or blended well. Finally, they were dried and packed with the previous methods. Jun 5, 2024 · Granulation involves the assembly of particles by creating bonds between them through compression or the use of binding agents. This is often done to make tablets in medicine. Yet, it remains popular and relevant among manufacturers. thus dry manufacturing process is used to increase the flow properties by decreasing the particle surface and reducing the amount of dust granulation. Screw configuration applied for twin-screw wet granulation. This literature review examines various wet granulation methods as well as innovative technologies used to optimize the granulation process. Short description. 10 mesh screen. Wet granulation Method: Active pharmaceutical ingredient (API) and all the other excipients, as mentioned in Table 1, were accurately weighed and were passed through 60 mesh sieve in order to remove foreign material and to get uniform particle size. Solutions of the binding agent are added to the mixed powder with stirring. This method combines dry powders with a liquid binder, such as water or a solvent, to form a cohesive mass. Hardness test Using a motorized tablet hardness tester (Campbell Electronics, Model HT-30/50, India), the crushing strength of each of ten tablets per batch was determined. The Process is Complex Without Machines. 3 Flowchart of dry granulation process; 9. Wet Granulation: Wet granulation is required to avoid the destruction of active components in the powder. Wet Granulation Technique, By Using Different Types Of Binders Preparation And Evaluation Of Aspirin Granules Prepared By Wet Granulation Technique, By Using Different Types Of Binders Sachin Dudhe , P. Wet granulation is used in pharmaceutical production to enhance formulation qualities such as flowability, compressibility, etc. Twenty tablets from each batch were used for the test. [3] . Reprinted from (Shirazian et al. The machines used to blend powders and add liquid are called “granulators”. Wet granulation reduces the amount of air entrapment thereby increasing Jan 7, 2025 · 9 Techniques/ Methods Used in Tablet Formulation. The role of wet granulation in tablet manufacturing is remarkable for its numerous advantages like improved methods Dry granulation Direct compression Blending Compression ISSN: 0974 – 9446 50 ake it . Aspirin, lactose and half the quantity of starch were weighed and mixed thoroughly. Figure 1: Wet Granulation process for effervescent tablets. Tableting of the powder blend without any prior granulation step. The granules formed by wet granulation are more compressible and compactible as compared to granules prepared by dry granulation; therefore, a wet granulation process was used to manufacture this product using water as a granulating agent. Aug 1, 2017 · Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures August 2017 Asian Journal of Pharmaceutical Mar 1, 2018 · We designed a 240-mg tablet containing 60 mg API-A. At present, according to the methods to promote the adhesion of powder particles, the granulation technology can be divided into two types, dry granulation and wet granulation [8]. Dry granulation and wet granulation are widely used in the pharmaceutical industry, despite the various operational processes involved in the wet granulation process tablets by wet granulation method B. Some pharmaceutical companies opt for dry granulation and other methods because wet granulation can be complex. Generally Effervescent tablets can be prepared by Wet granulation, Dry granulation & Compression. 3 Manufacture of tablets by direct compression method Feb 18, 2016 · It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. Granules are the basic portions in the midst of arrangement of tablets. Lissy Joice 3 1 PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207, Tamilnadu, India. • This due to the greater probability that the granulation will meet all the physical requirements for the compression of good tablets. Wet granulation process simply involves wet massing [8-15] of the powder blend with a granulating liquid, wet sizing and drying The process can be very simple or very complex depending on the characteristics of the powders, the final objective of tablet making, and the equipment that is available. 1. Sep 12, 2024 · Granulation is typically divided into three commonly used types: wet granulation, which uses a liquid, dry granulation, which does not and hot-melt granulation. 5, 1:1, 1:2 & 1:3 respectively by In the Preformulation study of co-processed excipients, it was found that a granule of size 18# has good flow properties and were directs the way and method of formulation. Sep 4, 2024 · This process enhances the flow properties, compressibility, and content uniformity of the powder blend, making it easier to handle and process into tablets. There are two primary methods of granulation: wet granulation and dry granulation. Types of Wet Granulation : Further Wet Granulation generally classified on the basis of Manufacturing Process : By using Planetary Mixer The usual methods of formulation include wet granulation, dry granulation and direct compression. This study aimed to compare the properties of tablets prepared by the wet granulation method using bacterial cellulose prepared by different methods as a diluent, using acetaminophen as a model drug. S; H igh Shear Granulator – By Ozioko, C; Granulation Techniques and Technologies: Recent Progresses – By Shanmugam, S; Wet Granulation Process for Tablet Manufacturing – By Tipa, P; Pharmaceutical Blending and Mixing – Edited by Cullen P. Drug and the diluent (Lactose) were sifted through sieve No. The produced granules were characterized in terms of granule size Manufacture of tablets employing wet granulation method Wet granulation method of tablet manufacturing was employed with milled date palm as a binding agent and water as the granulating liquid. API sensitive to elevated temperatures and/or moisture: yes; Suitable powder blend: through Wet granulation is a widely used technique that produces granules via wet massing of the active pharma ingredient (API) and granulation liquid with or without a binder. Jun 16, 2023 · Wet granulation method is a process of size enlargement in which fine powder particles are agglomerated or brought together into larger, strong and relatively permanent structure called granules using a suitable non-toxic granulating fluid such as water, isopropanol or ethanol (or mixtures thereof). Oct 9, 2017 · Aspirin tablet is prepared by wet granulation method. Granulation is a process of producing granules generally. qvillttqnnzmabjajrlfowcqhjvqmthocayuzyxosndkrtwiystwtmdegtixldrhziwcwowpznizp